Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

Strong epidemiological and experimental evidence indicate that both age and hypertension lead to significant functional and structural impairment of the cerebral microcirculation, predisposing to the development of vascular cognitive impairment (VCI) and Alzheimer’s disease. Preclinical studies esta...

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Detalhes bibliográficos
Publicado no:Age (Dordr)
Main Authors: Tarantini, Stefano, Tucsek, Zsuzsanna, Valcarcel-Ares, M. Noa, Toth, Peter, Gautam, Tripti, Giles, Cory B., Ballabh, Praveen, Wei, Jeanne Y., Wren, Jonathan D., Ashpole, Nicole M., Sonntag, William E., Ungvari, Zoltan, Csiszar, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061685/
https://ncbi.nlm.nih.gov/pubmed/27613724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-016-9931-0
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