AMPK/α-ketoglutarate axis dynamically mediates DNA demethylation in the Prdm16 promoter and brown adipogenesis

Promoting brown adipose tissue (BAT) development is an attractive strategy for the treatment of obesity, as activated BAT dissipates energy through thermogenesis; however, the mechanisms controlling BAT formation are not fully understood. We hypothesized that as a master regulator of energy metaboli...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Yang, Qiyuan, Liang, Xingwei, Sun, Xiaofei, Zhang, Lupei, Fu, Xing, Rogers, Carl J, Berim, Anna, Zhang, Shuming, Wang, Songbo, Wang, Bo, Foretz, Marc, Viollet, Benoit, Gang, David R., Rodgers, Buel D., Zhu, Meijun, Du, Min
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061633/
https://ncbi.nlm.nih.gov/pubmed/27641099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.08.010
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