Antidrug Antibody Formation in Oncology: Clinical Relevance and Challenges

In oncology, an increasing number of targeted anticancer agents and immunotherapies are of biological origin. These biological drugs may trigger immune responses that lead to the formation of antidrug antibodies (ADAs). ADAs are directed against immunogenic parts of the drug and may affect efficacy...

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Bibliographic Details
Published in:Oncologist
Main Authors: van Brummelen, Emilie M.J., Ros, Willeke, Wolbink, Gertjan, Beijnen, Jos H., Schellens, Jan H.M.
Format: Artigo
Language:Inglês
Published: AlphaMed Press 2016
Subjects:
New Drug Development and Clinical Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061540/
https://ncbi.nlm.nih.gov/pubmed/27440064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2016-0061
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