Fixed Dosing of Monoclonal Antibodies in Oncology

Most monoclonal antibodies in oncology are administered in body–size‐based dosing schedules. This is believed to correct for variability in both drug distribution and elimination between patients. However, monoclonal antibodies typically distribute to the blood plasma and extracellular fluids only,...

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Bibliografski detalji
Izdano u:Oncologist
Glavni autori: Hendrikx, Jeroen J.M.A., Haanen, John B.A.G., Voest, Emile E., Schellens, Jan H.M., Huitema, Alwin D.R., Beijnen, Jos H.
Format: Artigo
Jezik:Inglês
Izdano: AlphaMed Press 2017
Teme:
New Drug Development and Clinical Pharmacology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634778/
https://ncbi.nlm.nih.gov/pubmed/28754722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2017-0167
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