Fixed Dosing of Monoclonal Antibodies in Oncology

Most monoclonal antibodies in oncology are administered in body–size‐based dosing schedules. This is believed to correct for variability in both drug distribution and elimination between patients. However, monoclonal antibodies typically distribute to the blood plasma and extracellular fluids only,...

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Detalhes bibliográficos
Publicado no:Oncologist
Main Authors: Hendrikx, Jeroen J.M.A., Haanen, John B.A.G., Voest, Emile E., Schellens, Jan H.M., Huitema, Alwin D.R., Beijnen, Jos H.
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2017
Assuntos:
New Drug Development and Clinical Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634778/
https://ncbi.nlm.nih.gov/pubmed/28754722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2017-0167
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