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Targeting DNA Mismatches with Rhodium Metalloinsertors

DNA has been exploited as a biological target of chemotherapeutics since the 1940s. Traditional chemotherapeutics, such as cisplatin and DNA-alkylating agents, rely primarily on increased uptake by rapidly proliferating cancer cells for therapeutic effects, but this strategy can result in off-target...

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Bibliografische gegevens
Gepubliceerd in:Inorganica Chim Acta
Hoofdauteurs: Boyle, Kelsey M., Barton, Jacqueline K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061454/
https://ncbi.nlm.nih.gov/pubmed/27746507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ica.2016.01.021
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