MicroRNA-mediated downregulation of the potassium channel Kv4.2 contributes to seizure onset

Seizures are bursts of excessive synchronized neuronal activity, suggesting that mechanisms controlling brain excitability are compromised. The voltage-gated potassium channel Kv4.2, a major mediator of hyperpolarizing A-type currents in the brain, is a crucial regulator of neuronal excitability. Kv...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Gross, Christina, Yao, Xiaodi, Engel, Tobias, Tiwari, Durgesh, Xing, Lei, Rowley, Shane, Danielson, Scott Walter, Thomas, Kristen Therese, Jimenez-Mateos, Eva Maria, Schroeder, Lindsay Michelle, Pun, Raymund Yu Kwan, Danzer, Steve Craig, Henshall, David Clifford, Bassell, Gary Jonathan
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061042/
https://ncbi.nlm.nih.gov/pubmed/27681419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.074
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