Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein.

We report here that the negative cell cycle regulator protein p53 is an in vivo and in vitro substrate for protein kinase C, a cellular receptor for the tumor-promoter phorbol esters. We also demonstrate that p53 interacts in a calcium-dependent manner with S100b, a member of the S100 protein family...

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Bibliografiske detaljer
Main Authors: Baudier, J, Delphin, C, Grunwald, D, Khochbin, S, Lawrence, J J
Format: Artigo
Sprog:Inglês
Udgivet: 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC50606/
https://ncbi.nlm.nih.gov/pubmed/1454855
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