Nitric oxide released from JS-K induces cell death by mitotic catastrophe as part of necrosis in glioblastoma multiforme

The nitric oxide (NO) donor JS-K is specifically activated by glutathione S-transferases (GSTs) in GST-overexpressing cells. We have shown the induction of cell death in glioblastoma multiforme (GBM) cells at high JS-K doses but the mechanism remains unclear. The aim of this study was to determine w...

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Detalles Bibliográficos
Publicado en:Cell Death Dis
Main Authors: Günzle, Jessica, Osterberg, Nadja, Saavedra, Joseph E, Weyerbrock, Astrid
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059858/
https://ncbi.nlm.nih.gov/pubmed/27584787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.254
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