Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells

CD47 signaling in endothelial cells has been shown to suppress angiogenesis, but little is known about the link between CD47 and endothelial senescence. Herein, we demonstrate that the thrombospondin-1 (TSP1)-CD47 signaling pathway is a major mechanism for driving endothelial cell senescence. CD47 d...

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Foilsithe in:Cell Death Dis
Main Authors: Gao, Qi, Chen, Kexin, Gao, Lu, Zheng, Yang, Yang, Yong-Guang
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059850/
https://ncbi.nlm.nih.gov/pubmed/27607583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.155
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