Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells

CD47 signaling in endothelial cells has been shown to suppress angiogenesis, but little is known about the link between CD47 and endothelial senescence. Herein, we demonstrate that the thrombospondin-1 (TSP1)-CD47 signaling pathway is a major mechanism for driving endothelial cell senescence. CD47 d...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Gao, Qi, Chen, Kexin, Gao, Lu, Zheng, Yang, Yang, Yong-Guang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059850/
https://ncbi.nlm.nih.gov/pubmed/27607583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.155
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