Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity

Hepatic insulin signalling involves insulin receptor substrates (Irs) 1/2, and is normally associated with the inhibition of gluconeogenesis and activation of lipogenesis. In diabetes and obesity, insulin no longer suppresses hepatic gluconeogenesis, while continuing to activate lipogenesis, a state...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Kubota, Naoto, Kubota, Tetsuya, Kajiwara, Eiji, Iwamura, Tomokatsu, Kumagai, Hiroki, Watanabe, Taku, Inoue, Mariko, Takamoto, Iseki, Sasako, Takayoshi, Kumagai, Katsuyoshi, Kohjima, Motoyuki, Nakamuta, Makoto, Moroi, Masao, Sugi, Kaoru, Noda, Tetsuo, Terauchi, Yasuo, Ueki, Kohjiro, Kadowaki, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059684/
https://ncbi.nlm.nih.gov/pubmed/27708333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12977
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