Suberoylanilide hydroxamic acid attenuates paraquat-induced pulmonary fibrosis by preventing Smad7 from deacetylation in rats

BACKGROUND: Recent evidence suggests that a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), has anti-fibrotic effect. However, the exact mechanism of its anti-fibrotic potential remains is unclear. In this study, we investigated the molecular mechanism of SAHA in attenuating p...

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Bibliografiske detaljer
Udgivet i:J Thorac Dis
Main Authors: Rao, Shan-Shan, Zhang, Xiang-Yan, Shi, Ming-Jun, Xiao, Ying, Zhang, Ying-Ying, Wang, Yuan-Yuan, Zhang, Chang-Zhi, Shao, Song-Jun, Liu, Xin-Mei, Guo, Bing
Format: Artigo
Sprog:Inglês
Udgivet: AME Publishing Company 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059239/
https://ncbi.nlm.nih.gov/pubmed/27747000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jtd.2016.08.08
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