Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS)

The orphan nuclear receptor NR4A1 is expressed in tumors from rhabdomyosarcoma (RMS) patients and Rh30 and RD RMS cell lines, and we used RNA interference (RNAi) to investigate the role of this receptor in RMS cells. Knockdown of NR4A1 in Rh30 cells decreased cell proliferation, induced Annexin V st...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Lacey, Alexandra, Hedrick, Erik, Li, Xi, Patel, Ketan, Doddapaneni, Ravi, Singh, Mandip, Safe, Stephen
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058754/
https://ncbi.nlm.nih.gov/pubmed/27144436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9112
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