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Targeting of the epidermal growth factor receptor with mesoporphyrin IX-peptide conjugates

The synthesis and in vitro evaluation of four mesoporphyrin IX-peptide conjugates designed to target EGFR, over-expressed in colorectal and other cancers, are reported. Two peptides with known affinity for EGFR, LARLLT (1) and GYHWYGYTPQNVI (2), were conjugated to mesoporphyrin IX (MPIX, 3) via one...

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Detalhes bibliográficos
Publicado no:J Porphyr Phthalocyanines
Main Authors: Fontenot, Krystal R., Ongarora, Benson G., LeBlanc, Logan E., Zhou, Zehua, Jois, Seetharama D., Vicente, M. Graça H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058426/
https://ncbi.nlm.nih.gov/pubmed/27738394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1142/S1088424616500115
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