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An improved reversibly dimerizing mutant of the FK506-binding protein FKBP
FK506-binding protein (FKBP) is a monomer that binds to FK506, rapamycin, and related ligands. The F36M substitution, in which Phe36 in the ligand-binding pocket is changed to Met, leads to formation of antiparallel FKBP dimers, which can be dissociated into monomers by ligand binding. This FKBP(M)...
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| Udgivet i: | Cell Logist |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5058350/ https://ncbi.nlm.nih.gov/pubmed/27738551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21592799.2016.1204848 |
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