A high-throughput-compatible assay to measure the degradation of endogenous Huntingtin proteins

AIM: The accumulation of disease-causing proteins is a common hallmark of many neurodegenerative disorders. Measuring the degradation of such proteins using high-throughput-compatible assays is highly desired for the identification of genetic and chemical modulators of degradation. For example, Hunt...

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Vydáno v:Acta Pharmacol Sin
Hlavní autoři: Wu, Peng, Lu, Ming-xing, Cui, Xiao-tian, Yang, He-qing, Yu, Shen-liang, Zhu, Jian-bin, Sun, Xiao-li, Lu, Boxun
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5057231/
https://ncbi.nlm.nih.gov/pubmed/27264314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.31
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