N-Terminus of the Protein Kinase CLK1 Induces SR Protein Hyper-Phosphorylation

SR proteins are essential splicing factors that are regulated through multisite phosphorylation of their RS (arginine-serine-rich) domains by two major families of protein kinases. The SRPKs efficiently phosphorylate the arginine-serine dipeptides in the RS domain using a conserved docking groove in...

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Pubblicato in:Biochem J
Autori principali: Aubol, Brandon E., Plocinik, Ryan M., Keshwani, Malik M., McGlone, Maria L., Hagopian, Jonathan C., Ghosh, Gourisankar, Fu, Xiang-Dong, Adams, Joseph A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056641/
https://ncbi.nlm.nih.gov/pubmed/24869919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140494
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