Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons

Mutations in the gene MAPT encoding tau, a microtubules-associated protein, cause a subtype of familial neurodegenerative disorder, known as frontotemporal lobar degeneration tauopathy (FTLD-Tau), which presents with dementia and is characterized by atrophy in the frontal and temporal lobes of the b...

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Udgivet i:Sci Rep
Main Authors: Imamura, Keiko, Sahara, Naruhiko, Kanaan, Nicholas M., Tsukita, Kayoko, Kondo, Takayuki, Kutoku, Yumiko, Ohsawa, Yutaka, Sunada, Yoshihide, Kawakami, Koichi, Hotta, Akitsu, Yawata, Satoshi, Watanabe, Dai, Hasegawa, Masato, Trojanowski, John Q., Lee, Virginia M.-Y., Suhara, Tetsuya, Higuchi, Makoto, Inoue, Haruhisa
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056519/
https://ncbi.nlm.nih.gov/pubmed/27721502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34904
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