Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding

Sortilin is a multi-ligand sorting receptor that interacts with B100-containing VLDL and LDL as well as other ligands including neurotensin (NT). The current study investigates the hypothesis that phosphatidylinositol (3,4,5)-trisphosphate (PIP3) generated downstream of insulin action can directly b...

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Veröffentlicht in:Biochem Biophys Res Commun
Hauptverfasser: Sparks, Robert P., Jenkins, Jermaine L., Miner, Gregory E., Wang, Yan, Guida, Wayne C., Sparks, Charles E., Fratti, Rutilio A., Sparks, Janet D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056161/
https://ncbi.nlm.nih.gov/pubmed/27666481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2016.09.108
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