Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila

Transposable elements (TEs) are mobile genetic elements, highly enriched in heterochromatin, that constitute a large percentage of the DNA content of eukaryotic genomes. Aging in Drosophila melanogaster is characterized by loss of repressive heterochromatin structure and loss of silencing of reporte...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Wood, Jason G., Jones, Brian C., Jiang, Nan, Chang, Chengyi, Hosier, Suzanne, Wickremesinghe, Priyan, Garcia, Meyrolin, Hartnett, Davis A., Burhenn, Lucas, Neretti, Nicola, Helfand, Stephen L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056045/
https://ncbi.nlm.nih.gov/pubmed/27621458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604621113
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