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Active Site Metal Occupancy and Cyclic Di-GMP Phosphodiesterase Activity of Thermotoga maritima HD-GYP

HD-GYPs make up a subclass of the metal-dependent HD phosphohydrolase superfamily and catalyze conversion of cyclic di(3′,5′)-guanosine monophosphate (c-di-GMP) to 5′-phosphoguanylyl-(3′→5′)-guanosine (pGpG) and GMP. Until now, the only reported crystal structure of an HD-GYP that also exhibits c-di...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biochemistry
Main Authors: Miner, Kyle D., Kurtz, Donald M.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055813/
https://ncbi.nlm.nih.gov/pubmed/26786892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01227
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