Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation

BACKGROUND: In malaria-endemic areas, the first exposure to malaria antigens often occurs in utero when the fetal immune system is poised towards the development of tolerance. Children exposed to placental malaria have an increased risk of clinical malaria in the first few years of life compared to...

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Publicado en:Malar J
Autores principales: Prahl, Mary, Jagannathan, Prasanna, McIntyre, Tara I., Auma, Ann, Farrington, Lila, Wamala, Samuel, Nalubega, Mayimuna, Musinguzi, Kenneth, Naluwu, Kate, Sikyoma, Esther, Budker, Rachel, Vance, Hilary, Odorizzi, Pamela, Nayebare, Patience, Ategeka, John, Kakuru, Abel, Havlir, Diane V., Kamya, Moses R., Dorsey, Grant, Feeney, Margaret E.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055709/
https://ncbi.nlm.nih.gov/pubmed/27717402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-016-1545-6
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