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The Expression of PHOSPHO1, nSMase2 and TNAP is Coordinately Regulated by Continuous PTH Exposure in Mineralising Osteoblast Cultures

Sustained exposure to high levels of parathyroid hormone (PTH), as observed in hyperparathyroidism, is catabolic to bone. The increase in the RANKL/OPG ratio in response to continuous PTH, resulting in increased osteoclastogenesis, is well established. However, the effects of prolonged PTH exposure...

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Библиографические подробности
Опубликовано в: :Calcif Tissue Int
Главные авторы: Houston, D. A., Myers, K., MacRae, V. E., Staines, K. A., Farquharson, C.
Формат: Artigo
Язык:Inglês
Опубликовано: Springer US 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055575/
https://ncbi.nlm.nih.gov/pubmed/27444010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-016-0176-9
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