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A Bayesian Adaptive Design for Estimating the Maximum Tolerated Dose Curve using Drug Combinations in Cancer Phase I Clinical Trials
We present a cancer phase I clinical trial design of a combination of two drugs with the goal of estimating the maximum tolerated dose curve in the two-dimensional Cartesian plane. A parametric model is used to describe the relationship between the doses of the two agents and the probability of dose...
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| 出版年: | Stat Med |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5055414/ https://ncbi.nlm.nih.gov/pubmed/27060889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6961 |
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