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A Bayesian Adaptive Design for Cancer Phase I Trials Using a Flexible Range of Doses

We present a Bayesian adaptive design for dose finding in cancer phase I clinical trials. The goal is to estimate the maximum tolerated dose (MTD) after possible modification of the dose range during the trial. Parametric models are used to describe the relationship between the dose and the probabil...

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Pubblicato in:J Biopharm Stat
Autori principali: Tighiouart, Mourad, Cook-Wiens, Galen, Rogatko, André
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832533/
https://ncbi.nlm.nih.gov/pubmed/28858566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2017.1372774
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