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A Bayesian Adaptive Design for Cancer Phase I Trials Using a Flexible Range of Doses

We present a Bayesian adaptive design for dose finding in cancer phase I clinical trials. The goal is to estimate the maximum tolerated dose (MTD) after possible modification of the dose range during the trial. Parametric models are used to describe the relationship between the dose and the probabil...

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Detalhes bibliográficos
Publicado no:J Biopharm Stat
Main Authors: Tighiouart, Mourad, Cook-Wiens, Galen, Rogatko, André
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832533/
https://ncbi.nlm.nih.gov/pubmed/28858566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2017.1372774
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