The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer

Breast tumors often display extreme genetic heterogeneity characterized by hundreds of gross chromosomal aberrations and tens of thousands of somatic mutations. Tumor evolution is thought to be ongoing and driven by multiple mutagenic processes. A major outstanding question is whether primary tumors...

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Publicado en:Sci Adv
Main Authors: Law, Emily K., Sieuwerts, Anieta M., LaPara, Kelly, Leonard, Brandon, Starrett, Gabriel J., Molan, Amy M., Temiz, Nuri A., Vogel, Rachel Isaksson, Meijer-van Gelder, Marion E., Sweep, Fred C. G. J., Span, Paul N., Foekens, John A., Martens, John W. M., Yee, Douglas, Harris, Reuben S.
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2016
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055383/
https://ncbi.nlm.nih.gov/pubmed/27730215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601737
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