Altered fibrinolysis in autosomal dominant thrombomodulin-associated coagulopathy

Thrombomodulin-associated coagulopathy (TM-AC) is a newly recognized dominant bleeding disorder in which a p.Cys537Stop variant in the thrombomodulin (TM) gene THBD, results in high plasma TM levels and protein C-mediated suppression of thrombin generation. Thrombin in complex with TM also activates...

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Vydáno v:Blood
Hlavní autoři: Burley, Kate, Whyte, Claire S., Westbury, Sarah K., Walker, Mary, Stirrups, Kathleen E., Turro, Ernest, Chapman, Oliver G., Reilly-Stitt, Christopher, Mutch, Nicola J., Mumford, Andrew D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2016
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5054699/
https://ncbi.nlm.nih.gov/pubmed/27436851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-05-716092
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