IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans

BACKGROUND: The General Control Nonderepressible 2 (GCN2) kinase is a conserved member of the integrated stress response (ISR) pathway that represses protein translation and helps cells to adapt to conditions of nutrient shortage. As such, GCN2 is required for longevity and stress resistance induced...

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Détails bibliographiques
Publié dans:BMC Biol
Auteurs principaux: Ferraz, Rafael C., Camara, Henrique, De-Souza, Evandro A., Pinto, Silas, Pinca, Ana Paula F., Silva, Richard C., Sato, Vitor N., Castilho, Beatriz A., Mori, Marcelo A.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5054600/
https://ncbi.nlm.nih.gov/pubmed/27717342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-016-0301-2
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