Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis

Alterations in microRNA (miRNA) processing have been previously linked to aging. Here we used the small molecule enoxacin to pharmacologically interfere with miRNA biogenesis and study how it affects aging in C. elegans. Enoxacin extended worm lifespan and promoted survival under normal and oxidativ...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Redox Biol
Egile Nagusiak: Pinto, Silas, Sato, Vitor N., De-Souza, Evandro A., Ferraz, Rafael C., Camara, Henrique, Pinca, Ana Paula F., Mazzotti, Diego R., Lovci, Michael T., Tonon, Guilherme, Lopes-Ramos, Camila M., Parmigiani, Raphael B., Wurtele, Martin, Massirer, Katlin B., Mori, Marcelo A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2018
Gaiak:
Short Communication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037660/
https://ncbi.nlm.nih.gov/pubmed/29986212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.06.006
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