IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans

BACKGROUND: The General Control Nonderepressible 2 (GCN2) kinase is a conserved member of the integrated stress response (ISR) pathway that represses protein translation and helps cells to adapt to conditions of nutrient shortage. As such, GCN2 is required for longevity and stress resistance induced...

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Detalhes bibliográficos
Publicado no:BMC Biol
Main Authors: Ferraz, Rafael C., Camara, Henrique, De-Souza, Evandro A., Pinto, Silas, Pinca, Ana Paula F., Silva, Richard C., Sato, Vitor N., Castilho, Beatriz A., Mori, Marcelo A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5054600/
https://ncbi.nlm.nih.gov/pubmed/27717342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-016-0301-2
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