HMG-CoAR expression in male breast cancer: relationship with hormone receptors, Hippo transducers and survival outcomes

Male breast cancer (MBC) is a rare hormone-driven disease often associated with obesity. HMG-CoAR is the central enzyme of the mevalonate pathway, a molecular route deputed to produce cholesterol and steroid-based hormones. HMG-CoAR regulates the oncogenic Hippo transducers TAZ/YAP whose expression...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Di Benedetto, Anna, Mottolese, Marcella, Sperati, Francesca, Ercolani, Cristiana, Di Lauro, Luigi, Pizzuti, Laura, Vici, Patrizia, Terrenato, Irene, Shaaban, Abeer M., Sundara-Rajan, Sreekumar, Humphries, Matthew P., Barba, Maddalena, Speirs, Valerie, De Maria, Ruggero, Maugeri-Saccà, Marcello
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5054365/
https://ncbi.nlm.nih.gov/pubmed/27713571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35121
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