mTORC1-mediated downregulation of COX2 restrains tumor growth caused by TSC2 deficiency

Tuberous sclerosis complex (TSC), caused by loss-of-function mutations in the TSC1 or TSC2 gene, is characterized by benign tumor formation in multiple organs. Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) is the primary alteration underlying TSC tumors. By analyzing Tsc2-null...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Li, Hongwu, Jin, Fuquan, Jiang, Keguo, Ji, Shuang, Wang, Li, Ni, Zhaofei, Chen, Xianguo, Hu, Zhongdong, Zhang, Hongbing, Liu, Yehai, Qin, Yide, Zha, Xiaojun
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053737/
https://ncbi.nlm.nih.gov/pubmed/27078846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8633
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items