High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition

The anti-apoptotic protein B cell lymphoma/leukaemia 2 (BCL-2) is highly expressed in neuroblastoma and plays an important role in oncogenesis. In this study, the selective BCL-2 inhibitor ABT199 was tested in a panel of neuroblastoma cell lines with diverse expression levels of BCL-2 and other BCL-...

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Pubblicato in:Oncotarget
Autori principali: Bate-Eya, Laurel T., den Hartog, Ilona J.M., van der Ploeg, Ida, Schild, Linda, Koster, Jan, Santo, Evan E., Westerhout, Ellen M., Versteeg, Rogier, Caron, Huib N., Molenaar, Jan J., Dolman, M. Emmy M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053701/
https://ncbi.nlm.nih.gov/pubmed/27056887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8547
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