High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition

The anti-apoptotic protein B cell lymphoma/leukaemia 2 (BCL-2) is highly expressed in neuroblastoma and plays an important role in oncogenesis. In this study, the selective BCL-2 inhibitor ABT199 was tested in a panel of neuroblastoma cell lines with diverse expression levels of BCL-2 and other BCL-...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bate-Eya, Laurel T., den Hartog, Ilona J.M., van der Ploeg, Ida, Schild, Linda, Koster, Jan, Santo, Evan E., Westerhout, Ellen M., Versteeg, Rogier, Caron, Huib N., Molenaar, Jan J., Dolman, M. Emmy M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053701/
https://ncbi.nlm.nih.gov/pubmed/27056887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8547
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