High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition

The anti-apoptotic protein B cell lymphoma/leukaemia 2 (BCL-2) is highly expressed in neuroblastoma and plays an important role in oncogenesis. In this study, the selective BCL-2 inhibitor ABT199 was tested in a panel of neuroblastoma cell lines with diverse expression levels of BCL-2 and other BCL-...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Bate-Eya, Laurel T., den Hartog, Ilona J.M., van der Ploeg, Ida, Schild, Linda, Koster, Jan, Santo, Evan E., Westerhout, Ellen M., Versteeg, Rogier, Caron, Huib N., Molenaar, Jan J., Dolman, M. Emmy M.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053701/
https://ncbi.nlm.nih.gov/pubmed/27056887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8547
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