Expression of cancer related BRCA1 missense variants decreases MMS-induced recombination in Saccharomyces cerevisiae without altering its nuclear localization

BRCA1 tumor suppressor gene is found mutated in familial breast and ovarian cancer. Most cancer related mutations were found located at the RING (Really Interesting New Gene) and at the BRCT (BRca1 C-Terminal) domain. However, 20 y after its identification, the biological role of BRCA1 and which dom...

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Publicado en:Cell Cycle
Main Authors: Lodovichi, Samuele, Vitello, Martina, Cervelli, Tiziana, Galli, Alvaro
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2016
Assuntos:
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053555/
https://ncbi.nlm.nih.gov/pubmed/27484786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1215389
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