Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation

Hepcidin is the key regulator of systemic iron availability that acts by controlling the degradation of the iron exporter ferroportin. It is expressed mainly in the liver and regulated by iron, inflammation, erythropoiesis and hypoxia. The various agents that control its expression act mainly via th...

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Udgivet i:PLoS One
Main Authors: Asperti, Michela, Stuemler, Tanja, Poli, Maura, Gryzik, Magdalena, Lifshitz, Lena, Meyron-Holtz, Esther G., Vlodavsky, Israel, Arosio, Paolo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053418/
https://ncbi.nlm.nih.gov/pubmed/27711215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164183
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