Novel N‐allyl/propargyl tetrahydroquinolines: Synthesis via Three‐component Cationic Imino Diels–Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors

New N‐allyl/propargyl 4‐substituted 1,2,3,4‐tetrahydroquinolines derivatives were efficiently synthesized using acid‐catalyzed three components cationic imino Diels–Alder reaction (70–95%). All compounds were tested in vitro as dual acetylcholinesterase and butyryl‐cholinesterase inhibitors and thei...

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Detalhes bibliográficos
Publicado no:Chem Biol Drug Des
Main Authors: Rodríguez, Yeray A., Gutiérrez, Margarita, Ramírez, David, Alzate‐Morales, Jans, Bernal, Cristian C., Güiza, Fausto M., Romero Bohórquez, Arnold R.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053295/
https://ncbi.nlm.nih.gov/pubmed/27085663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12773
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