The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells

Nicotinic acetylcholine receptors (nAChRs) binding to the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces Ca(2+) signalling, a mechanism that is implicated in various human cancers. In this study, we investigated the role of NNK-mediated Ca(2+) signalling in...

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Pubblicato in:Nat Commun
Autori principali: Boo, Hye-Jin, Min, Hye-Young, Jang, Hyun-Ji, Yun, Hye Jeong, Smith, John Kendal, Jin, Quanri, Lee, Hyo-Jong, Liu, Diane, Kweon, Hee-Seok, Behrens, Carmen, Lee, J. Jack, Wistuba, Ignacio I., Lee, Euni, Hong, Waun Ki, Lee, Ho-Young
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052689/
https://ncbi.nlm.nih.gov/pubmed/27666821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12961
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