Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets, glycoprotein (GP)Ib–IX receptor complex has been long suggested to be a shear sensor and receptor. Recently, a relatively unstable and mechanosensitive domain in the GPIbα subunit of GPIb–IX was identified. He...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Deng, Wei, Xu, Yan, Chen, Wenchun, Paul, David S., Syed, Anum K., Dragovich, Matthew A., Liang, Xin, Zakas, Philip, Berndt, Michael C., Di Paola, Jorge, Ware, Jerry, Lanza, Francois, Doering, Christopher B., Bergmeier, Wolfgang, Zhang, X. Frank, Li, Renhao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052631/
https://ncbi.nlm.nih.gov/pubmed/27670775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12863
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