Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode

The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in the regulation of the metabolic homeostasis and therefore represent valuable therapeutic targets for the treatment of metabolic diseases. The development of more balanced drugs interacting with PPARs, devoid of...

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Foilsithe in:Sci Rep
Main Authors: Capelli, Davide, Cerchia, Carmen, Montanari, Roberta, Loiodice, Fulvio, Tortorella, Paolo, Laghezza, Antonio, Cervoni, Laura, Pochetti, Giorgio, Lavecchia, Antonio
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052532/
https://ncbi.nlm.nih.gov/pubmed/27708429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34792
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