Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity

Cancers often evade immune surveillance by adopting peripheral tissue–tolerance mechanisms, such as the expression of programmed cell death ligand 1 (PD-L1), the inhibition of which results in potent antitumor immunity. Here, we show that cyclin-dependent kinase 5 (Cdk5), a serine-threonine kinase t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Science
Main Authors: Dorand, R. Dixon, Nthale, Joseph, Myers, Jay T., Barkauskas, Deborah S., Avril, Stefanie, Chirieleison, Steven M., Pareek, Tej K., Abbott, Derek W., Stearns, Duncan S., Letterio, John J., Huang, Alex Y., Petrosiute, Agne
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5051664/
https://ncbi.nlm.nih.gov/pubmed/27463676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aae0477
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados