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Cdk5 controls IL-2 gene expression via repression of the mSin3a-HDAC complex

Cyclin-dependent kinase 5 (Cdk5) is a unique member of a family of serine/threonine cyclin-dependent protein kinases. We previously demonstrated disruption of Cdk5 gene expression in mice impairs T-cell function and ameliorates T-cell-mediated neuroinflammation. Here, we show Cdk5 modulates gene exp...

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Détails bibliographiques
Publié dans:Cell Cycle
Auteurs principaux: Lam, Eric, Pareek, Tej K, Letterio, John J
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614394/
https://ncbi.nlm.nih.gov/pubmed/25785643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.987621
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