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SMARCAL1 Resolves Replication Stress at ALT Telomeres

Cancer cells overcome replicative senescence by exploiting mechanisms of telomere elongation, a process often accomplished by reactivation of the enzyme telomerase. However, a subset of cancer cells lack telomerase activity and rely on the alternative lengthening of telomeres (ALT) pathway, a recomb...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Cox, Kelli E., Maréchal, Alexandre, Flynn, Rachel Litman
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5051350/
https://ncbi.nlm.nih.gov/pubmed/26832416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.01.011
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