Pioglitazone Ameliorates Smooth Muscle Cell Proliferation in Cuff-Induced Neointimal Formation by Both Adiponectin-Dependent and -Independent Pathways

The aim of this study is to elucidate to what degree adiponectin is involved in TZD-mediated amelioration of neointimal formation. We investigated the effect of 3- or 8-weeks’ pioglitazone on cuff-induced neointimal formation in adiponectin-deficient (APN-KO) and wild-type (WT) mice. Pioglitazone fo...

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Published in:Sci Rep
Main Authors: Kubota, Tetsuya, Kubota, Naoto, Sato, Hiroyuki, Inoue, Mariko, Kumagai, Hiroki, Iwamura, Tomokatsu, Takamoto, Iseki, Kobayashi, Tsuneo, Moroi, Masao, Terauchi, Yasuo, Tobe, Kazuyuki, Ueki, Kohjiro, Kadowaki, Takashi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050439/
https://ncbi.nlm.nih.gov/pubmed/27703271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34707
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