Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer

Aspirin prevents cardiovascular disease and colon cancer; however aspirin's inhibition of platelet COX-1 only partially explains its diverse effects. We previously identified an aspirin response signature (ARS) in blood consisting of 62 co-expressed transcripts that correlated with aspirin'...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Voora, Deepak, Rao, A. Koneti, Jalagadugula, Gauthami S., Myers, Rachel, Harris, Emily, Ortel, Thomas L., Ginsburg, Geoffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5049978/
https://ncbi.nlm.nih.gov/pubmed/27566955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.08.021
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