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Platelet PKC-θ deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1
OBJECTIVE: Mutations in hematopoietic transcription factor RUNX1 cause thrombocytopenia and impaired platelet function. In a patient with a heterozygous mutation in RUNX1 we have described decreased platelet pleckstrin phosphorylation and protein kinase C-θ (PKC-θ, gene PRKCQ) associated with thromb...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3066073/ https://ncbi.nlm.nih.gov/pubmed/21252065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.221879 |
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