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Endogenous miRNA and Target Concentrations Determine Susceptibility to Potential ceRNA Competition

Target competition (ceRNA crosstalk) within miRNA-regulated gene networks has been proposed to influence biological systems. To assess target competition, we characterize and quantitate miRNA networks in two cell types. Argonaute iCLIP reveals that hierarchical binding of high- to low-affinity miRNA...

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Vydáno v:Mol Cell
Hlavní autoři: Bosson, Andrew D., Zamudio, Jesse R., Sharp, Phillip A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048918/
https://ncbi.nlm.nih.gov/pubmed/25449132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.018
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