Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies

Anti-CD20 monoclonal antibodies (mAbs) represent an effective treatment for a number of B cell malignancies and autoimmune disorders. Glycoengineering of anti-CD20mAb may contribute to increased anti-tumor efficacy through enhanced antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (AD...

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Udgivet i:Sci Rep
Main Authors: Grandjean, Capucine L., Montalvao, Fabricio, Celli, Susanna, Michonneau, David, Breart, Beatrice, Garcia, Zacarias, Perro, Mario, Freytag, Olivier, Gerdes, Christian A., Bousso, Philippe
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048169/
https://ncbi.nlm.nih.gov/pubmed/27698437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34382
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